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In recent years, oligopeptide-1 has emerged as a standout ingredient in the cosmetics industry. This highly active skincare component has gained significant attention, appearing in numerous high-end formulations. But what exactly makes it so popular and effective?   What is Oligopeptide-1?   Oligopeptide-1, also called as tripeptide-1, is a small molecule composed of three amino acids, designed to mimic the body’s natural signaling peptides. Its unique structure allows it to penetrate deep into the skin and “communicate” with skin cells, activating repair and regeneration mechanisms.     The Key Benefits of Oligopeptide-1   Oligopeptide-1 has become a sought-after ingredient thanks to its wide-ranging skincare benefits:   Boosts Collagen Production As we age, collagen levels in the skin decline, leading to wrinkles and loss of elasticity. Oligopeptide-1 stimulates fibroblasts to produce collagen, helping to firm the skin and reduce fine lines.   Repairs the Skin Barrier It strengthens the skin’s natural barrier, improving resilience and protecting against environmental damage. This makes it especially beneficial for sensitive skin.   Accelerates Skin Healing Mimicking the effects of growth factors, oligopeptide-1 promotes faster cell turnover and repair, making it effective for reducing acne scars and addressing damaged skin.   Antioxidant and Anti-Inflammatory Properties Oligopeptide-1 combats free radical damage while soothing inflammation, helping maintain a calm and healthy complexion.   Why Are More People Choosing Products with Oligopeptide-1 ?   Effective Yet Gentle: Oligopeptide-1 works in harmony with the skin’s natural processes and is non-irritating, making it suitable for all skin types, including sensitive skin.   Backed by Science: Research has demonstrated that oligopeptide-1 significantly increases collagen production and improves skin quality, earning it credibility in the skincare world.     Versatile Benefits: Beyond anti-aging, it addresses multiple skin concerns, offering a comprehensive approach to skincare.     Oligopeptide-1 has become a favorite in the cosmetics industry due to its exceptional anti-aging, repair, and protective properties. It not only helps maintain youthful-looking skin but also addresses a variety of skin concerns. With its versatility and effectiveness, it’s no wonder oligopeptide-1 is celebrated as a powerhouse ingredient. Adding a product with oligopeptide-1 to your skincare routine could be your next step toward healthier, more radiant skin!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

  Small-molecule peptides have become a trending ingredient in skincare, often touted for their anti-aging benefits. But do they truly live up to the hype when it comes to reducing wrinkles? Let’s explore the science behind their effectiveness.   What Are Small-Molecule Peptides?   Small-molecule peptides are short chains of 2–10 amino acids with low molecular weight, making them easy to absorb through the skin. Once they penetrate the skin barrier, they act directly on the dermis. Common types include tetrapeptides, hexapeptides, and copper peptides, known for stimulating collagen production, enhancing skin elasticity, and providing antioxidant protection.   How Do They Work Against Wrinkles?   1.Stimulating Collagen Production Collagen loss is a key factor in wrinkle formation. Small-molecule peptides activate fibroblasts, boosting collagen synthesis to improve skin firmness and reduce fine lines and wrinkles.   2.Antioxidant Protection Free radicals can damage skin cells and accelerate aging. Small-molecule peptides have antioxidant properties that neutralize free radicals, reducing oxidative stress from UV exposure and pollution.   3.Relaxing Facial Muscles Some peptides, like hexapeptides, block nerve signals to relax facial muscles, effectively softening expression lines such as crow’s feet and forehead wrinkles.   Is There Scientific Evidence?   Studies show that consistent use of peptide-infused skincare products can visibly improve skin elasticity and smoothness within weeks. For instance, 0.1% tetrapeptide-1(0.1mg/mL DropPet® TR-1P) has a collagen-promoting effect, which has been found to significantly reduce crow’s feet and nasolabial folds. However, the effectiveness depends on factors like peptide concentration, formulation, and absorption. Poorly designed products may fail to deliver the desired results.     How to Choose Skincare with Small-Molecule Peptides?   1.Check the Ingredients: Look for clearly labeled peptides like tetrapeptides, hexapeptides, or copper peptides.   2.Prioritize Concentration: Higher peptide concentrations typically yield better results.   3.Be Consistent: Long-term use, combined with good skincare habits like sun protection and hydration, enhances effectiveness.   Conclusion   Small-molecule peptides show promising results in reducing wrinkles, particularly by stimulating collagen production and combating oxidative stress. While they’re not a “magic cure,” they are a valuable tool for slowing down the signs of aging. With the right product and consistent use, small-molecule peptides could become your go-to ally in the fight against wrinkles.     Your skin is in a race against time—small-molecule peptides might just be the secret to staying ahead!   If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

Surfactants, classified under the “catalysts and various auxiliaries” branch of the fine chemicals industry, are an indispensable part of modern production. Often referred to as the “MSG of the industrial world,” they find applications across virtually all fine chemical sectors, including industrial processes, agriculture, personal care, and new material development.   In recent years, personal care and cleaning products have become two of the most significant global consumer markets. Surfactants are key ingredients in these products and are among the substances that come into frequent contact with the skin. Depending on their hydrophilic-lipophilic balance (HLB) value, surfactants can serve multiple functions, such as cleaning, foaming, emulsifying, wetting, dispersing, and solubilizing.   However, many widely used surfactants, such as alkyl sulfonates and alkyl sulfates, are directly applied to the skin in rinse-off personal care products like shampoos and body washes. These compounds may cause skin irritation and allergic reactions, raising concerns about their safety.   Sophorolipids: A Safer, Eco-Friendly Alternative     Sophorolipids, a class of glycolipid biosurfactants produced by yeast fermentation, have gained attention for their unique properties. They are non-toxic, biodegradable, and environmentally friendly, making them one of the most promising natural surfactants with significant market potential.   Sophorolipids provide multiple benefits, including:   Functional Advantages: Effective at dispersing, wetting, retaining moisture, lubricating, and emulsifying. Mild surfactant properties suitable for sensitive applications. Gentle antibacterial effects, efficiently inhibiting Propionibacterium acnes and Lactobacillus. Anti-inflammatory activity, reducing the release of inflammatory cytokines. Inhibition of lipase activity, preventing the breakdown of sebum into free fatty acids.   Skin Benefits: Stimulates dermal fibroblast metabolism and promotes collagen synthesis. Neutralizes free radicals and inhibits elastase activity, enhancing skin elasticity and repair. Activates macrophages and supports fibrinolytic functions.   Environmental and Safety Features: Heat-resistant and stable across a wide pH range. Safe and non-toxic with no irritation to the skin. Fully biodegradable and environmentally sustainable.   Growing Market Adoption   Due to their exceptional performance and safety profile, sophorolipids have already been adopted by leading international brands in personal care and cosmetic products. These end-use products are now widely available in markets across the EU, the US, Japan, and China.

Adenosine is a common active ingredient in skincare products, valued for its potential anti-aging and skin-repairing properties. Here are some of the key benefits of adenosine for the skin: Adenosine boosts the energy metabolism of skin cells and stimulates collagen production, which helps to smooth fine lines and wrinkles while improving skin elasticity and firmness.It also strengthens the skin barrier, contributing to a smoother and healthier complexion. Adenosine has anti-inflammatory properties that can soothe sensitive skin and reduce redness and irritation caused by inflammation. Adenosine stimulates microcirculation in the skin, improving dullness and making skin look more radiant and healthy. Adenosine is often considered a gentle active ingredient for all skin types, including sensitive skin. Precautions： The concentration of adenosine in skincare products is generally low (0.1%-1%), which is sufficient to be effective without irritating the skin. Adenosine can work synergistically with other anti-aging ingredients (e.g., niacinamide, vitamin C), but avoid using it together with ingredients that may cause irritation (e.g., high concentrations of fruit acids).

Sensitive skin often struggles with redness, irritation, and an impaired skin barrier, making it prone to discomfort and inflammation. Vitamin B12 (cobalamin), has emerged as an ideal ingredient for soothing and restoring sensitive skin due to its unique anti-inflammatory and reparative properties. One of the highlights of Vitamin B12 is its excellent anti-inflammatory effects. Dermatitis symptom scores decreased significantly more on the side treated with VB12 cream than on the side treated with blank cream. By reducing the level of inflammation, Vitamin B12 relieves redness and irritation, providing an immediate soothing effect on damaged skin. In addition, vitamin B12 plays a key role in repairing the skin barrier. It promotes protein synthesis, particularly the production of keratin and collagen, which are essential for maintaining the skin's protective layer. A strengthened barrier not only helps lock in moisture, but also protects against external stimuli, thus making the skin less sensitive. Vitamin B12 also possesses powerful antioxidant properties that neutralize free radicals and reduce oxidative stress caused by environmental factors such as UV rays and pollution. This protective effect further reduces the feeling of skin irritation and supports skin health. There are three different specifications of DropCare® VB12 availabled to customers. Gentle and highly effective, Vitamin B12 brings significant improvement to sensitive skin through its multiple actions of soothing, repairing, and protecting, while enhancing the skin's resilience and comfort.

Mandelic acid is an alpha hydroxy acid (AHA) with a relatively large molecular structure, which means it penetrates the skin more slowly and is therefore considered gentler compared to other acids. Due to its lipophilic nature, mandelic acid is particularly suitable for oily and acne-prone skin. Its oil-regulating effects include the following: 1. Dissolving Oil in Pores: Mandelic acid can penetrate deep into the pores to help dissolve excess sebum, clearing out debris that clogs pores and reducing the formation of blackheads and acne. 2. Regulating Oil Secretion: By removing excess oil from the pores, mandelic acid gradually helps balance oil secretion, leaving the skin less shiny and with a fresher appearance. 3. Gentle Exfoliation: As a mild AHA, mandelic acid promotes the shedding of dead skin cells, making the skin smoother and more radiant. This gentle exfoliation helps prevent clogged pores caused by excess buildup.   In addition, mandelic acid has antibacterial and skin-brightening properties, making it suitable for regular use. When using mandelic acid, it’s recommended to introduce it gradually and always pair it with good sun protection to achieve optimal skincare benefits.

Retinoids are substances that are similar in structure and function to retinol, including: Drugs such as retinoic acid (RA), isotretinoin, adapalene, tazarotene, etc.; Retinol (retinol), retinaldehyde, retinyl palmitate, retinyl propionate, retinyl retinoate, and now the up-and-coming hydroxypinazone retinoate (HPR), among others. These substances can be converted into each other, so that there is a transformation pathway: After the body absorbs retinol, if it can't consume it, it converts it into retinyl palmitate and stores it, and when needed, hydrolyzes the palmitate bond with esterase (the red position in the retinol ester structure diagram on the right is broken), and retinol is released.Retinol is stripped of a hydrogen atom and oxidized to become retinaldehyde, which is an intermediate state. Retinaldehyde is further oxidized, adding an oxygen atom that becomes retinoic acid.Retinoic acid (tretinoin/retinoid) is the actual form of retinoid that enters the nucleus to bind to trans-retinoin reaction elements (RAR/RXR) and initiates the corresponding gene expression. It not only retains the efficacy group of tretinoin, but can directly bind to the receptor; It also covers the irritating groups and improves the physical and chemical stability. Cosmetics containing HPR (Hydroxypinacolone Retinoate)  can be used even on VA-sensitive skin, but note that pregnant women should not use them!        

A quick and easy way to get a healthy wheat-skin tone is to apply a tanning product. When selecting a tanning product, people tend to choose different products based on the degree of color they want to achieve. In fact, the main efficacy substance of most products is dihydroxyacetone(DHA). The dosage of dihydroxyacetone(DHA) added determines the final degree of coloration of the product on the skin. So what's the mechanism of dihydroxyacetone discoloration on the skin? Dihydroxyacetone and proteins in the skin undergo a Malanin reaction, turning the cuticle proteins brown.The specific reaction principle is as follows: Dihydroxyacetone(DHA) does not damage the skin, and is considered a safe skin coloring agent. The color is not removed by simple washing, swimming, or natural perspiration, but it only lasts for 5 to 7 days, as skin cells are continuously being shed. Exfoliation, tape stripping, prolonged water submersion, or heavy sweating can lighten the tan, as these all contribute to rapid dead skin cell pealing. Today, dihydroxyacetone(DHA) is the main active ingredient in virtually all sunless tanning skincare preparations. The above pictures were taken from some subjects in a clinical experiment of DropBio. The coloring was recorded after 3 consecutive times (once a day) of using Instant Tanning Mousse with 10% DropBio@ DHA, and the subsequent fading was continuously recorded. So Dihydroxyacetone(DHA) is a very effective ingredient for self-tanning.  

As we all know, ceramide is a lipid that is similar in structure to the substance that makes up the cuticle of the skin, so it can quickly penetrate the skin and maintain the renewal of the skin's natural protective layer, maintain the balance of natural hydration. When combined with the moisture in the cuticle, it can form a net-like structure to firmly lock the moisture. Ceramide is an important skin-activating ingredient in the cuticle that strengthens the skin barrier, rebuilds cells, and reduces the effects of the external environment by forming effective skin surface barriers.      When Ceramide is added to the damaged skin, the composition of the lipids between the cells is improved and the cells on the surface of the skin become compact and regular again.While the moisture inside the skin is locked in, the outside irritation and bacteria can no longer penetrate the skin's surface, effectively reducing sensitivity and acne formation, so Ceramide is a safe, natural and highly effective skin care ingredient.

In daily life, preservatives are a topic that often sparks extensive discussion and concern. Many question their safety, worried about potential health impacts. Yet, with advancements in technology and increasingly stringent regulations, the safety and effectiveness of modern preservatives are largely assured.   Preservatives inhibit microbial growth and prevent the spoilage of products like food and cosmetics. They are crucial for extending shelf life and ensuring product safety. Despite their long used history, safety doubts persist. However, after scientific research and rigorous safety evaluations, many modern preservatives have proven safe. When used within prescribed limits, they don't harm health. Their effectiveness is also widely acknowledged. They can effectively restrain the growth of bacteria,mold and yeasts, preventing product deterioration and ensuring quality and safety.   DropPrev® MPB is a safe and effective halogen-free preservative, a thymol isomer with high stability, low odor, and good safety. Being halogen - free, it's suitable for oral and skin care. It outperforms thymol in antibacterial activity, effectively inhibiting and killing bacteria,mold, and yeasts, thus preventing product spoilage. It also absorbs UV and inhibits oxidation, protecting products from light, temperature, air, and humidity, and prolonging shelf life. Moreover, it's highly safe, free from halogens and heavy metals, and suitable for pharmaceuticals, quasi drugs and cosmetics.   In cosmetics and skincare, DropPrev® MPB penetrates dental plaque biofilms to eliminate periodontal pathogens, offering professional antibacterial protection. Its mild astringency also provides a pleasant feel in cosmetics.     If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

In today’s beauty landscape, plant extracts have emerged as the new darling of cosmetics. Consumers are increasingly drawn to the natural and sustainable benefits these ingredients offer. With an emphasis on harnessing nature’s bounty, brands are formulating products that promise gentle yet effective care, free from harsh chemicals. This trend not only speaks to a growing eco-conscious mindset but also highlights the efficacy of botanical ingredients in promoting healthier, more radiant skin.   Outstanding Examples of Botanical Excellence   Numerous plant extract-based products have already made a significant impact in the market. For instance, green tea extract is celebrated for its potent antioxidant properties and ability to reduce inflammation, making it a staple in anti-aging formulations. Aloe vera, known for its soothing and hydrating qualities, is frequently found in products designed to calm and moisturize sensitive skin. Other exemplary extracts, such as chamomile for its calming effects and rosehip oil for its regenerative properties, illustrate the diverse benefits of botanicals that modern skincare brands are leveraging to address various skin concerns.   The Advantages of Phyllacantha fibrosa Extract   Among the myriad of plant-based ingredients, phyllacantha fibrosa extract stands out for its exceptional benefits. Sourced from deep-sea algae, this extract is rich in natural polysaccharides and a variety of active substances that deliver superior moisturizing, repair, and anti-wrinkle effects. It not only deeply nourishes the skin and reinforces the protective barrier but also promotes cell regeneration, leading to a smoother, firmer, and more youthful complexion. With its high safety profile and proven efficacy, our phyllacantha fibrosa extract and a mixture of marine algae and flavonoids represent a pinnacle of innovation in botanical skincare, offering a holistic solution for those seeking both immediate and lasting improvements.     If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.

  As we age, the natural levels of collagen and elastin in the skin decrease, leading to signs of aging such as sagging, fine lines, and wrinkles. To address these concerns, skincare products often incorporate hydrolyzed protein ingredients, such as hydrolyzed collagen and hydrolyzed elastin, which help nourish the skin and support its health.   Hydrolyzed Collagen   Hydrolyzed collagen is a small-molecule peptide derived from breaking down natural collagen. It provides several skincare benefits:   Moisturizing Effect: Hydrolyzed collagen helps to attract and retain moisture, keeping the skin hydrated and improving dryness and roughness.   Improved Skin Elasticity: Its small molecular size makes it easily absorbed by the skin, promoting collagen synthesis and enhancing skin elasticity and firmness.   Anti-Aging: By stimulating collagen production, hydrolyzed collagen helps reduce the appearance of fine lines and wrinkles, slowing down the skin’s aging process.   Hydrolyzed Elastin   Hydrolyzed elastin is derived from breaking down elastin, and it offers the following skincare benefits:   Enhanced Skin Elasticity: Hydrolyzed elastin helps restore the skin’s elasticity, reducing sagging and firmness loss.   Skin Repair: Rich in amino acids, it promotes skin cell regeneration and speeds up the healing process for damaged skin.   Antioxidant Properties: Hydrolyzed elastin has antioxidant properties that protect the skin from free radical damage, slowing down signs of aging.   In conclusion, both hydrolyzed collagen and hydrolyzed elastin are key ingredients in skincare that provide effective moisture, enhance elasticity, and help combat the signs of aging, supporting overall skin health.       If you are interested in our products and want to know more details, please contact judyzhou@drop-bio.com.