Bromelain Protease extracted from pineapple 100%pure natural with gentle exfoliation

In 1876 bromelain was discovered. Later, in 1957,Heinicke found high concentrations of bromelain in pineapple stems.From then on ,Bromelain is treated as a medical treatment.

Bromelain is the main component of thiol protein hydrolysis.

Pineapple proteinase contains peroxide enzyme, acid phosphatase, several kinds of protease inhibitors and Organic bonded calcium.

FDA considers Bromelain to be generally safe and classify as a food additive.

• Bromelain is considered to have very low toxicity, with an LD50 greater than 10 g/kg.
• The dosage of 1.5 g/kg/ day has no carcinogenic or teratogenic effect on rats.
• In human clinical trials, side effects are generally not observed.

By chemical digestion of keratin cell cohesion, stimulation of stripping.

This proteolytic enzyme breaks down proteins into smaller pieces, causing the skin to soften and keratinocytes to shed.

Unlike AHAs, their activity does not depend on pH, but is activated by water.

We think the bromelain to CD128a/CXCR1 and CD128b/CXCR2 receptor protein hydrolysis has weakened the chemotactic kinase, dielectric guide of integrin affinity thus resulting in a decline in the adhesion of the observed.

Importantly, neutrophil migration stimulated by the bacterial peptide receptor fMLP was not affected by bromelain treatment, suggesting that bromelain does not cause an overall defect in leukocyte migration.